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Ursochol poate creste absorbtia ciclosporinei din intestin. De aceea, pacientilor tratati cu ciclosporina trebuie sa li se monitorizeze concentratiile plasmatice de ciclosporina si daca este necesar se vor ajusta dozele de ciclosporina. In cazuri izolate, Ursochol poate reduce absorbtia ciprofloxacinei. Trebuie atentionati sa nu utilizeze acest medicament: pacientii care au colici biliare frecvente, cu infectii grave, modificari ale pancreasului sau afectiuni intestinale care pot afecta circulatia enterohepatica a acizilor biliari (rezectia sau ileostomia, ileita regionala). Deoarece medicamentul contine lactoza, administrarea nu este recomandata la pacientii cu intoleranta. Tratamentul nu se administreaza la copii. A nu se pastra la indemana copiilor. Sarcina si alaptarea: In studiile la animal au fost demonstrate efecte teratogene la o specie; la om, nu exista suficienta. De aceea Ursochol este contraindicat in timpul primului trimestru de sarcina, nandrorapid 100 mg injectable steroids durabolin, npp. Inaintea inceperii tratamentului trebuie exclusa existenta unei eventuale sarcini. Femeile de varsta fertila care utilizeaza Ursochol trebuie sa foloseasca o metoda de contraceptie adecvata. Din al doilea trimestru de sarcina, medicul poate indica Ursochol numai daca este absolut necesar, dupa o apreciere adecvata a raportului risc fetal/beneficiu matern al terapiei. Deoarece nu sunt disponibile suficiente informatii privind excretia acidului ursodeoxicolic in laptele matern, Ursochol nu trebuie utilizat in timpul alaptarii. Capacitatea de a conduce vehicule sau de a folosi utilaje. Nu exista dovezi privind efecte ale produsului asupra atentiei si a timpului de reactie ale pacientilor. Doze si mod de administrare. Pentru dizolvarea calculilor biliari cu continut de colesterol, doza este de 300-600 mg pe zi (dupa sau in timpul meselor) coreaspunzator la 2-4 comprimate de Ursochol a 150 mg sau 1-2 comprimate Ursochol a. Pentru a mentine conditiile favorabile pentru dizolvarea calculilor biliari existenti, tratamentul trebuie sa dureze cel putin 4-6 luni pana la 12 luni sau mai mult, in functie de dimensiunea calculilor si evolutia sub tratament. Pentru tratamentul de mentinere sunt suficiente doze de 150 mg de 2 ori pe zi sau de 300 mg o data pe zi. In sindroamele dispeptice biliare, doza este de 1 comprimat a 150 mg de 2 ori pe zi. In hepatopatii cronice cu colestaza doza poate fi crescuta pana la 300 mg de 2-3 ori pe zi. Durata tratamentului trebuie hotarata de medic in functie atat de tipul si severitatea afectiunii cat si de raspunsul terapeutic. Dozele pot fi modificate de medic. Calculii biliari se pot calcifica in timpul tratamentului cu Ursochol. Ocazional, poate sa apara urticarie si in cazuri rare materiile fecale pot deveni pastoase.
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