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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosterone, with weight loss at 4 weeks and re-weighting at four weeks after the end of the trial. The men were randomly assigned to either the Weight Watchers weight loss scheme plus testosterone, or a placebo at baseline. Weight gain was not measured.
At weeks 0, 3 and 6, the subjects were given a 3-point visual analogue scale (0 to 10) to gauge their appetite. At weeks 4, 8 and 10, the volunteers were given a questionnaire to measure their level of general wellbeing with a score of ≥6.
At weeks 0 and 3, the testosterone supplement had similar results to the placebo, with both groups gaining less weight (p-value<0.001 for both groups) without significant difference between the two groups in fat mass, body weight or body fat percentage ( Table 1 ). Mean weight gain was −0.9 kg for the Weight Watchers group plus testosterone, compared to −1.3 kg for the placebo group. After three weeks, both groups had similar levels of general wellbeing. Mean weight loss for the Weight Watchers group at 3 and 4 weeks was also comparable to that for the placebo.
Between weeks 0 and 5, the volunteers were asked to complete a questionnaire measuring how often they felt hungry and at what time-points (pre- and post-treatment) they felt full. For the men, on average, they felt full between meals and for the women they felt full between meals and at bedtime. Of the 25 women who completed a questionnaire at baseline, 25 women completed this questionnaire at the end of the Weight Watchers programme, compared to 19 women who completed the questionnaire at baseline (P = 0.02 for the difference).
Participants (N = 24) completed the scale at baseline, two months after the start of the Weight Watchers programme (month zero) and in the follow-up period after one year of follow-up: at baseline (N = 8), three months post-treatment (N = 12) and six months post-treatment (N = 20).
Weight loss at the end of the weight loss phase was not significantly different between the weight loss programme plus testosterone and the placebo (p = 0.14) but there was a statistically significant difference between the weight loss programme plus testosterone and the placebo at the end of the six-month follow-up period (p = 0.04; Figure 2 ). Overall mean weight loss at the end of the six-month follow-up period was −0.2 kg
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