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Growth stimulation: Anabolic steroids were used heavily by pediatric endocrinologists for children with growth failure from the 1960s through the 1980s. The evidence available indicates that growth stimulation can also improve normal growth in children with growth failure by stimulating the adrenal gland (10), and in some cases by reducing cortisol levels (20).

The effects are relatively benign. In adult-age patients, cortisol in the blood is elevated from 5.00 mmol/L at a baseline concentration of 30.00 mmol/L (average 20 years past follow-up; range 17–60 mmol/L in adult studies) to an average of 37.40 to 48.00 mmol/L when supplemented with growth hormone; at a dose of 2.9 mg/kg bodyweight (20 mg/kg once daily or 1 mg/kg once and twice a day, for 2.9 and 30 days, respectively) and 2.9 and 30 mg/kg/day, respectively, as a single dose of growth hormone (14,15). If no effect is seen (or small) on overall growth, this decrease is considered a benefit; in most cases, the change is large enough to reduce the need for additional therapy (14). No significant changes on various parameters such as lean body mass or bone mineral density, and no adverse effects on renal function occurred when used for growth or development (13,26). Although growth inhibition studies are lacking, the most prominent effect of growth inhibition is a decrease in growth hormone concentrations from 3.0 to 1.5 IU/L [average 5 days past follow-up, range 1 month to 6 weeks to 6 months] in adult and growth-restricted children in a study of the effects of an injectable growth hormone (12), although the amount of increase varied from study to study (6,29). This increase indicates a growth suppression effect (Fig. 1), and may be attributable to inhibition of the action of growth hormone receptors (30). Fig. 1. Clinical manifestations in adult (3 to 12 months) and growth (12 to 18 months) patients, using injectable growth hormone (GHD). Dorsal striatum and medial frontal cortex represent corticotropin-releasing hormone response elements; bilateral hippocampus represents the hippocampus that mediates attention (31). There were decreases in total cortisol, blood lactate and systolic blood pressure (mean 8.4 mmol/L and 7.6 mmol/L, respectively) (4 and 7, respectively). The decreases in the total cortisol and blood lactate were most pronounced during growth and showed greater variability after 2 and 4 months of treatment (data not shown). There was

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2020 · цитируется: 13 — in particular, it appears that today’s men have become increasingly preoccupied with having a lean and muscular body, perhaps as a result of constant exposure. — medications that have been used for treating anabolic steroid withdrawal allow the natural hormonal system to restore. — study examines renal effects of steroids in bodybuilders new york (december 10, 2009) – anabolic steroids may help athletes gain muscle mass. Anabolic steroids may be addictive, and users may go through withdrawal. Prevention requires community education, as well as reviewing why adolescents may want