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Thus, an anavar and clenbuterol cycle will likely produce rapid fat loss, with moderate increases in lean muscle and strength. In addition, the fat lost during and after the cycle is stored as adipose tissue, and this tissue is then utilized for energy (21). However, the mechanism of fat loss during the anavar cycle has not been elucidated, and it could be that the mechanism results from a combination of other factors, particularly the effects of leptin, ketosis, and a lower than expected insulin response (22). Moreover, some of the effects of the anavar cycle and weight reduction might be due to more rapid insulin responses than expected. Thus, weight reduction should be carefully monitored during and after the anavar cycle if it leads to weight loss of ≥ 2.5 kg in 2 wk. Therefore, if such weight loss occurs, it should be considered a clinical emergency since it could lead to significant morbidity, especially if there is subcutaneous fat gain from the subcutaneous fat mass of the patient (23). It should be also considered that there is a risk of cardiac arrest or pulmonary oedema from the effects of the azo cycle on blood pressure (24).

Although the effects of the ketogenic diet have been well described, there are now reports of the metabolic effects of the ketogenic diet on a variety of tissues and organs (25–27). These include decreases in body weight (26), increases in lean mass (27,28), reductions in fat mass (27,29), and decreases in insulin levels (25,30–32,33,34) throughout the organism, especially in liver (35,36), muscle (33,37), and bone (35,38) ( ). These reports suggest that both the azo/ketogenic diet (AKD) and hypoglycemic diet might increase muscle and adipose tissue weight (32,35,37), which would further enhance the risk of obesity. In addition, many studies have suggested that weight reduction during the ketogenic diet is associated with increased insulin resistance, whereas weight gain may be induced by a very high carbohydrate (60–70%) diet (22,39). Therefore, it is possible that body weight may actually decrease in response to diets with more pronounced energy restriction. The ketogenic diet does not appear to promote lean muscle mass reduction, as previously reported by a study (29) of older adults. However, studies conducted on overweight subjects showed that a ketogenic diet significantly reduced adipose tissue (30,38). The potential mechanisms for these changes are beyond the scope of the present review.

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