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A randomized study on 76 children with steroid-resistant nephrotic syndrome, who were treated with a combination of tacrolimus and low-dose prednisone was found safe and effective (4)(Fig ). Table shows the safety and efficacy of 2 different therapy regimens for nephrotic syndrome in the trial.
Figure Open in a separate window Open in a separate window The primary analysis of the first part identified 20 children (Table ) with a high risk of toxicity in the tacrolimus-treated group.
The second part identified 19 children (Table ) who were not toxic after tacrolimus treatment and 16 who were not harmful in the low-dose prednisone group, fallout 76 scrapbox.
The trial was started before the use of the second phase of therapy for nephrotic syndrome was decided.
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