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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneesters alone or placebo. Both groups maintained a 12 week weight loss programme and no significant main effects were seen for BMI (P > 0.05). Baseline fasting glucose levels for the Weight Watchers and placebo groups remained significantly lower at 6 months (both P < 0.05) compared to baseline (Table 2). The mean BMI decreased in the Weight Watchers group by 1.75kg/m2 from baseline and 0.69kg/m2 from month 6 to 3 (P < 0.001). In the placebo cohort, the change was 0.61kg/m2 from baseline and 1.13kg/m2 from month 6 to 2 (P < 0.001). Mean fasting insulin levels (insulin on a gram scale for a fasting blood sample drawn 1 hour before) decreased from baseline by 9.15μU/mL to 0.83μU/mL at 6 months (P = 0.01), whereas the change in insulin on a glucometer from baseline to month 6 was 1.6% (P 0.05), fasting glucose or insulin or on insulin or systolic, diastolic or mean total cholesterol.
The study had a small number of participants and several potential weaknesses need to be highlighted. The study included a single 12 week programme rather than a larger programme that should be expected to include longer periods of weight loss and may therefore affect the results. The trial had a number of limitations including: noncompliance to study treatment and a lack of any baseline information for many participants. In order to assess the effect of testosterone supplementation, the participant’s hormone level should have been recorded and, if so, the sample size at baseline should also have been considered. Also, the study was open-ended with a 1 hour dietary test that may have been too short of duration, whereas this was not the case with the present analysis, although this may be less likely as the subjects were all in the same weight range during the dietary testing on both diets and may all have similar baseline hormones. Although a large number of participants were found to have the same baseline levels as
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