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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.8 g of nandrolone. In the case of prednisolone, treatment with a single dose (ie, 0.8 g) increases nandrolone and nandrolone conjugate concentrations for a period of 1.5 weeks after one oral dose. As previously noted, the peak serum concentrations of nandrolone are attained approximately 2 weeks after onset of treatment with prednisolone, as assessed by the CORT analysis, steroid injection muscle knots. The average peak concentration at 48 hours is ∼35 pmol/L, whereas the peak concentrations at 90 days are ∼35-60 pmol/L, a greater proportion of which is associated with a very potent and persistent inhibitory action of nandrolone on human steroidogenesis during this period.

The most striking finding from the studies described earlier was the presence of a large proportion of patients in our group who displayed a strong increase in the concentration of the metabolite of nandrolone, 4-hydroxy-nandrolone, in the venous blood following treatment, 5 prednisolone pantip mg. We believe this is indicative of the greater efficacy of nandrolone therapy at treating hypogonadism than did our drug-free group. The concentration of 4-hydroxy-nandrolone increases from 2- to 40 percent within 2- to 4-weeks after first treatment with nandrolone, and by 2 or more weeks after termination of treatment, the concentrations are close to zero in approximately half of the patients. The clinical data also indicate that patients in our study who received another dose of nandrolone or the second dose of an inactive comparator drug may exhibit a significant increase of 4-hydroxy-nandrolone in the venous blood, anabolics.com review. However, other studies reported an absence of systemic drug effects after administration of 4-hydroxy-nandrolone, prednisolone 5 mg pantip. In one series, the administration of 4-hydroxy-nandrolone produced little or no effect on thyroid function in 20 patients.14 In another series, 14 patients were administered 20 mg of nandrolone per day, and none showed a significant effect on any parameters.15

There are many unanswered issues that remain to be addressed. Several hypotheses have been advanced to explain the increased 4-hydroxy-nandrolone concentration during nandrolone treatment, https://spinor-m.ru/community/profile/gana23620448/.

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