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FIRST INFUSION: Initiate infusion at a rate of 50 mg/hr; in the absence of infusion toxicity, increase infusion rate by 50 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr. SUBSEQUENT INFUSIONS: STANDARD INFUSION: Initiate infusion at a rate of 100 mg/hr; in the absence of infusion toxicity, increase rate by 100 mg/hr increments at 30-minute intervals, to a maximum of 400 mg/hr. FOR PREVIOUSLY UNTREATED FOLLICULAR NON-HODGKIN’S LYMPHOMA (NHL) AND DIFFUSE LARGE B-CELL NHL (DLBCL) PATIENTS: If patients did not experience a Grade 3 or 4 infusion related adverse event during Cycle 1, a 90-minute infusion can be administered in Cycle 2 with a glucocorticoid-containing chemotherapy regimen : -Initiate infusion at a rate of 20% of the total dose given in the first 30 minutes and administer the remaining 80% of the total dose over the next 60 minutes. If the 90-minute infusion is tolerated in Cycle 2, the same rate can be used for subsequent cycles. Continue the infusion at one-half the previous rate upon improvement of symptoms. Comments : -Premedicate before each infusion with acetaminophen and an antihistamine. Use: Non-Hodgkin’s Lymphoma (NHL) : -Relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL as a single agent -Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to this drug in combination with chemotherapy, as single-agent maintenance therapy -Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first line CVP chemotherapy -Previously untreated diffuse large B-cell, CD20-positive NHL in combination with CHOP or other anthracycline-based chemotherapy regimens. Usual Adult Dose for Lymphoma. NOTE: Not all products are approved for the same indications or patient age populations. Refer to the manufacturer product information for indications. NON-HODGKIN’S LYMPHOMA (NHL) : 375 mg/m2 IV according to the following schedules : -Relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL: 375 mg/m2 IV once weekly for 4 or 8 doses. In patients with complete or partial response, initiate rituximab maintenance 8 weeks following completion of rituximab in combination with chemotherapy. Administer this drug as a single agent every 8 weeks for 12 doses. AS A COMPONENT OF IBRITUMOMAB TIUXETAN THERAPY FOR NHL: -Infuse rituximab 250 mg/m2 IV in accordance with the ibritumomab tiuxetan package insert. FIRST INFUSION: Initiate infusion at a rate of 50 mg/hr; in the absence of infusion toxicity, increase infusion rate by 50 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr. SUBSEQUENT INFUSIONS: STANDARD INFUSION: Initiate infusion at a rate of 100 mg/hr; in the absence of infusion toxicity, increase rate by 100 mg/hr increments at 30-minute intervals, to a maximum of 400 mg/hr. 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Use: Non-Hodgkin’s Lymphoma (NHL) : -Relapsed or refractory, low-grade or follicular, CD20-positive, B-cell NHL as a single agent -Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to this drug in combination with chemotherapy, as single-agent maintenance therapy -Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first line CVP chemotherapy -Previously untreated diffuse large B-cell, CD20-positive NHL in combination with CHOP or other anthracycline-based chemotherapy regimens. Usual Adult Dose for Rheumatoid Arthritis. NOTE: Not all products are approved for the same indications or patient age populations. Refer to the manufacturer product information for indications. 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