How would anabolic steroids affect a sedentary person
Further investigation into the comparative benefits conferred by trenbolone therapy relative to the current gold standard, testosterone, are well justified by these findings. Changes in Body Composition The most relevant effects for bodybuilders are the body composition changes seen with trenbolone treatment. The control rats that did NOT receive trenbolone gained eight percent body mass over the course of the study, with all of that gain (and then some) accounted for by an increase in fat mass. Body composition was measured by DEXA, so the results are reliable. The trenbolone-treated rats did not gain any significant mass during treatment. HOWEVER, there was a significant increase in lean mass, with a concordant reduction in fat mass. The trenbolone-treated rats saw a gain of 11 percent in lean mass, and dropped 37 percent of fat mass. Compare that to the unchanged lean mass of the control rats and 34 percent increase in fat mass. The results would be outrageous in a human study. This change in body composition was not overtly stressful to the organs or metabolism of the rats, how would anabolic steroids affect a sedentary person. In fact, the opposite occurred’ as it was discovered that the body became more sensitive to the signaling function of insulin. Insulin resistance precedes type 2 diabetes and is believed to play a role in a number of chronic diseases. The trenbolone-treated rats demonstrated a HOMA-IR score (measure of insulin resistance) that was roughly half that of the control rats. Additionally, and particularly relevant in light of the presumptive (and possibly incorrect) black box warning now being attached to pharmaceutical testosterone products, markers of cardiovascular risk IMPROVED for the trenbolone-treated rats. Those opposed to androgen replacement therapy would point out that HDL (good) cholesterol dropped by 57 percent. In fact, all cholesterol values dropped with the HDL:LDL ratio IMPROVING significantly, as well as a 51 percent drop in triglycerides. Further, when a heart attack was induced surgically, trenbolone-treated rats responded the same as the control rats, with no increase in tissue damage markers. The researchers suggest that the reduction in DHT, secondary to the suppression of endogenous testosterone, may have protected the heart from some of the ischemia reinjury (heart attack related) damage. Yes, endogenous testosterone fell considerably, as would be expected due to the negative feedback to the hypothalamic-pituitary-testes regulatory system. Further, the prostate was enlarged approximately 50 percent, but no evidence of malignancy was reported. In other words, it was ‘normal’ prostate growth and not cancer. This rat study mimics the anecdotal reports given by bodybuilders on the effects of trenbolone, at a dose range commonly practiced in that community. Improvement in body composition, with positive health markers and no overt evidence of organ damage in the studied tissues, is promising. Now, many bodybuilders have reported that trenbolone is difficult to tolerate, with accelerated hair loss, sleep disruption, erectile dysfunction, mood changes and ‘tren cough. However, the current findings further support investigating the use of trenbolone further, in contrast to previous papers suggesting a contribution to neurodegenerative conditions, such as Alzheimer’s.
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