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Anabolic steroids may raise lipoproteins that carry cholesterol in the bloodstream which may cause high cholesterol which may lead to long-term damage such as heart attack or strokes.
“We are advising people with premenopausal sex or those who have not had pregnancy in a few years to not use the drugs,” said Dr. James Karpidis, lead author of the study, which was published online in the journal JAMA Internal Medicine on Aug. 25, 2013.
Karpidis is chief of cardiology and director of cardiovascular medicine in the division of cardiac rehabilitation and cardiovascular outcomes at Cedars-Sinai Medical Center in Los Angeles.
A study published last year in the British medical journal Lancet found that a high-dose of dihydrotestosterone (DHT), a potent type of AAS, produced adverse cardiovascular effects in men over 40 who underwent a clinical trial of the drug (Citalopram) alone.
The drugs caused elevated triglycerides and lowered blood pressure but there were no significant decreases in heart disease risk.
The new paper was to determine if there is a relationship between testosterone and LDL or VLDL cholesterol and whether the increase in HDL (“good”) cholesterol seen after AAS use is associated with a lower risk of developing heart disease, says co-author Dr. John P. Pizzuto, senior clinical research scientist at Cedars-Sinai.
In the study, researchers compared the results of blood samples collected from 1,926 men taking the drugs alone or with a placebo for a period of two years to those from the same men taking dihydrotestosterone and cholesterol-lowering medication known as lovastatin.
Results showed that men taking dihydrotestosterone had elevated cholesterol, triglyceride and total cholesterol levels. They also had lower concentrations of HDL (good) and LDL (bad) cholesterol. They were also at greater risk of developing heart disease. They also had less weight gain than men taking the placebo.
Dr. Pizzuto suggested the risk of developing heart disease might be more pronounced among dihydrotestosterone users than among users of the drugs alone because they are being given doses that can cause greater changes in body composition than the doses in men who take the drugs as part of their regular routine.
Dr. Pizzuto, who was not involved in the study, says a higher body mass index (BMI) can increase LDL cholesterol levels for several reasons.
“Those that are more obese or with higher body mass index (BMI), the LDL cholesterol may be elevated because of their extra pounds,” he says. “So those subjects with the
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Clenbuterol and anabolic steroids: a previously unreported cause of. The extra red blood cells carry more oxygen to their straining muscles than in normal blood, giving them an edge in endurance. Similarly, many male athletes use. High blood pressure (hypertension); blood clots; fluid retention; high cholesterol